Ocular Disposition of ∆8-Tetrahydrocannabinol from Various Topical Ophthalmic Formulations

Polysaccharides as Excipients for Ocular Topical Formulations

A novel lidocaine hydrochloride ophthalmic gel for topical ocular anesthesia

Topical anesthetics play an important role in the practice of ophthalmology, both for procedures in the office and in the operating room. The need for safe, long-acting topical ocular anesthetic agents is ongoing, and has been highlighted by the increase of intravitreal administration of pharmacologic agents. Current practices for ocular anesthesia include subconjunctival injection of 2% aqueou...

Natural Bioadhesive Biodegradable Nanoparticle-Based Topical Ophthalmic Formulations for Management of Glaucoma.

PURPOSE We prepared and characterized topical ophthalmic formulations containing brimonidine-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles (NPs) for sustained release of brimonidine as once daily regimen for management of glaucoma. METHODS Nanoparticles were prepared using a spontaneous emulsification solvent diffusion method. Different concentrations of polymers, emu...

Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures

PURPOSE To review the current literature on safety, efficacy, and measures of surgeon and patient satisfaction with lidocaine hydrochloride gel as a tool for ocular anesthesia. METHODS Pubmed search using keywords "lidocaine gel," "ophthalmic," and "surgery" and compiling cross-references. Twenty-six total references were reviewed, including 15 prospective randomized controlled trials (RCTs, ...

New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance.

Two n-octenylsuccinate starch (AS) types of unknown molecular weights were assessed for ocular tolerance. Irritation potential of different solutions (containing 2 and 15% (w/w) AS) and AS stabilized emulsions (containing 15% (w/w) AS) was evaluated in vivo in rabbit eyes, using a confocal laser scanning microscope, and in vitro on treated excised pig corneas by light microscopy of histological...